Olea europaea L. var frantoye grown in Algeria – extracts characterization by HPLC/MS, polyphenols and hypoglycemic activitie

This research work aims to study the different components existing in the leaves and fruits of Olea europaea var frantoye and test their hypoglycemic effect on albino rats administered by 50 mg/kg, 250 mg/kg, and 500 mg/kg of aqueous leaves and fruits dissolved in normal saline (N/S). The results obtained show that the extracts of the leaves and fruits of the olive tree (Olea europaea) contain polyphenols; the phytochemical screening showed them to be rich in different components. The quantitative study confirmed this richness and the dominant molecule is Oleuropein (781,26 and 233,83 ppm, respectively, leaves and fruits). Albino diabetic rats treated with the high dose (500 mg/kg/b.wt) as the most effective dose for significant treatment. Compared to control groups. While the standard medication (positive control Glucophage 500) is effective compared to leaf and fruit extract.