The Effect of Chorionic Villus Sampling on Fetal Heart Rate

<i>Objective:</i> Fetal heart rate (FHR) variation during chorionic villus sampling (CVS) is a controversial topic. Limited studies have been published on this subject. Our study intended to evaluate the effects of CVS on the FHR. <i>Method:</i> One hundred and sixty-five patients undergoing first-trimester elective CVS for prenatal diagnosis of β-thalassemia were entered into a prospective study. M-mode FHR was obtained before and immediately after CVS in the patients. Potentially confounding variables also recorded included: gestational age, number of needle passes and placental location. <i>Results:</i> FHR values before and after CVS were compared using the paired t test and showed no statistically significant differences by 95% confidence. No differences were found in data analyzing gestational age, number of needle passes or placental location. <i>Conclusion:</i> We were unable to detect any significant change in FHR after performing CVS. It seems that FHR is generally not altered by CVS.