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Coralline Hydroxyapatite Keratoprosthesis in Rabbits
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ABSTRACTBACKGROUND: The ideal keratoprosthesis will have a curvature similar to that of the recipient cornea and allow the tissue to grow into the supporting material. We developed a support for a keratoprosthesis made of porous hydroxyapatite, which is highly biocompatible, biointegrable, non-biodegradable, and colonizable.METHODS: We implanted the keratoprosthesis unilaterally in the right eyes of 12 New Zealand rabbits, intralamellarly and between a homologous episclerokeratoplasty (with and without conjunctival flap) for 12 months. Pathology studies and technetium-99 bone scans were performed.RESULTS: We found good vascularization, no signs of infection or extrusion, no epithelial downgrowth, and no adverse tissue reaction.CONCLUSION: A clinical trial of this keratoprosthesis is warranted. [J Refract Surg 1997;13:74-78]
Title: Coralline Hydroxyapatite Keratoprosthesis in Rabbits
Description:
ABSTRACTBACKGROUND: The ideal keratoprosthesis will have a curvature similar to that of the recipient cornea and allow the tissue to grow into the supporting material.
We developed a support for a keratoprosthesis made of porous hydroxyapatite, which is highly biocompatible, biointegrable, non-biodegradable, and colonizable.
METHODS: We implanted the keratoprosthesis unilaterally in the right eyes of 12 New Zealand rabbits, intralamellarly and between a homologous episclerokeratoplasty (with and without conjunctival flap) for 12 months.
Pathology studies and technetium-99 bone scans were performed.
RESULTS: We found good vascularization, no signs of infection or extrusion, no epithelial downgrowth, and no adverse tissue reaction.
CONCLUSION: A clinical trial of this keratoprosthesis is warranted.
[J Refract Surg 1997;13:74-78].
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