Clinical evaluation of the efficacy of Vajraka ghrita in management of Vicharchika (atopic dermatitis/eczema) – A single arm clinical study

Background: Ayurveda, an ancient medical science, offers profound insights into skin health through its understanding of "Kushtha," a term encompassing various skin ailments. Ayurvedic texts detail the etiology, classification, prognosis, and treatment modalities for Kushtha, highlighting the significance of "Ghritakalpana" in its management. Ghritakalpanas, medicated ghee formulations, hold particular importance in Kushtha treatment. Material and Methods: This study delves into the efficacy of "Vajraka Ghrita," a specific Ghritakalpana mentioned in classical Ayurvedic texts, in managing "Vicharchika" - a type of Kshudrakushtha akin to Atopic Dermatitis/Eczema in modern medicine. The research methodology involves a comprehensive review of classical Ayurvedic literature to elucidate the conceptual framework of Ghritakalpana in Kushtha management. Additionally, clinical evaluation of Vajraka Ghrita's efficacy in Vicharchika management is conducted through a structured study design. It was a single arm clinical study with 40 subjects. The dose was 10 gms twice a day before meal with lukewarm water for a month. Results and Discussion: Preliminary findings indicate promising outcomes regarding the efficacy of Vajraka Ghrita in managing Vicharchika. By addressing symptoms such as severe itching, lichenification, and dryness, Vajraka Ghrita demonstrates potential as an adjunctive therapy for Atopic Dermatitis/Eczema. Vajraka Ghrita has very effective in treatment of Vicharchika about 7 patients having Marked relief which was >75%,29 patients having Moderate relief about 50-75%,3 patients having Mild relief 25-50%,1 patient having no relief i.e.< 25%.Further analysis and clinical trials are necessary to validate these findings and elucidate the mechanisms underlying Ghritakalpana's therapeutic effects. This study underscores the relevance of integrating ancient Ayurvedic wisdom with modern medical approaches for comprehensive healthcare delivery.