Structural and In-Vitro Characterization of Highly Swellable Β-Cyclodextrin Polymeric Nanogels Fabricated by Free Radical Polymerization for Solubility Enhancement of Rosuvastatin

Basic aim of the study was to potentiate solubility of Rosuvastatin by loading it in synthesized nanogels. A set of nine different formulations was fabricated by an optimized free radical polymerization technique. FTIR spectroscopy was performed for unloaded and loaded nanogels for determining the compatibility of constituents and drug with the system. Morphological characterization was performed by SEM. Particle size analysis was processed through zeta sizer. Swelling, in-vitro release and solubility studies were accomplished in different media. Similarly, results of in-vitro release of nanogels and commercially available tablet of Rosuvastatin were compared in different dissolution media. For the determination of safety profile, toxicity study was performed in healthy rabbits. FTIR spectroscopy confirmed the presence of corresponding peaks of respective functional groups of individual constituents and that of drug in unloaded and loaded nanogels. SEM images depicted fluffy appearance of nanogels with small pores inside the structure. The optimized formulation showed particle sizes in the range of 217.70 ± 2.23 for unloaded and 257.33 ± 2.11 for loaded nanogels. Percent drug loading, in-vitro drug release and solubility profiles were also satisfactory for all the synthesized nanogels. In comparison with commercially available tablet Rovista ® , in-vitro release profiles of synthesized nanogels showed better response. Moreover, biocompatibility of the synthesized nanogels was also confirmed by toxicity study. It was concluded that solubility of Rosuvastatin was potentially enhanced by nanogels and such formulation can also be used for other poorly soluble drugs.Basic aim of the study was to potentiate solubility of Rosuvastatin by loading it in synthesized nanogels. A set of nine different formulations was fabricated by an optimized free radical polymerization technique. FTIR spectroscopy was performed for unloaded and loaded nanogels for determining the compatibility of constituents and drug with the system. Morphological characterization was performed by SEM. Particle size analysis was processed through zeta sizer. Swelling, in-vitro release and solubility studies were accomplished in different media. Similarly, results of in-vitro release of nanogels and commercially available tablet of Rosuvastatin were compared in different dissolution media. For the determination of safety profile, toxicity study was performed in healthy rabbits. FTIR spectroscopy confirmed the presence of corresponding peaks of respective functional groups of individual constituents and that of drug in unloaded and loaded nanogels. SEM images depicted fluffy appearance of nanogels with small pores inside the structure. The optimized formulation showed particle sizes in the range of 217.70 ± 2.23 for unloaded and 257.33 ± 2.11 for loaded nanogels. Percent drug loading, in-vitro drug release and solubility profiles were also satisfactory for all the synthesized nanogels. In comparison with commercially available tablet Rovista ® , in-vitro release profiles of synthesized nanogels showed better response. Moreover, biocompatibility of the synthesized nanogels was also confirmed by toxicity study. It was concluded that solubility of Rosuvastatin was potentially enhanced by nanogels and such formulation can also be used for other poorly soluble drugs.