Controversial technologies in intramedullary osteosynthesis of rats femur fractures

The aim: to conduct a comparative study of osteoreparative regeneration, namely in the periosteal and intermediate areas of the cortex, during intramedullary osteosynthesis of the femur of rats with and without reaming of the bone marrow canal. Materials and methods. The work is based on the results of an experimental study conducted on 56 white mature laboratory rats, which simulated diaphyseal fracture of the femur and performed stable nail osteosynthesis with reaming of the bone marrow canal in the first series and without reaming in the second series of the experiment. Histological examination of the specimens was performed on the 7th, 14th, 28th and 90th day after surgery. Results. The procedure of reaming the bone marrow canal reduces the potential reparative capacity of bone tissue in the endosteal area and leads to “distorted” activation of the process of the cortex restructuring. There is a significant activation of osteoclastic resorption. Conclusions. Bone fusion is more active with the use of intramedullary fixator without reaming of the bone marrow canal, because its reaming reduces the manifestations of reparative potentials in the endosteal region and leads to excessive activation of the resorptive process of restructuring the cortex of both endosteal and central part