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Formulation and evaluation of solid dispersion method based fast dissolving tablet of cilnidipine
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Background: The objective of this work was to enhance the solubility and dissolution rate for rapid onset of anti-hypertensive action of cilnidipine. Method: To enhance the solubility of cilnidipine solvent evaporation method was used. In solvent evaporation method polymer like HPMC, PVP K30, PEG 4000 and PEG 6000(for binary solid dispersion) and poloxamer 188(for ternary solid dispersion) were used in the different drug polymer ratio. Conclusion: Among them cilnidipine: HPMC: poloxamer 188 shows better solubility and also different physical characterization test like DSC and XRD. After selection of best ternary solid dispersion fast dissolving tablets of cilnidipine were prepared using direct compration method via using different super disintegrant.
Title: Formulation and evaluation of solid dispersion method based fast dissolving tablet of cilnidipine
Description:
Background: The objective of this work was to enhance the solubility and dissolution rate for rapid onset of anti-hypertensive action of cilnidipine.
Method: To enhance the solubility of cilnidipine solvent evaporation method was used.
In solvent evaporation method polymer like HPMC, PVP K30, PEG 4000 and PEG 6000(for binary solid dispersion) and poloxamer 188(for ternary solid dispersion) were used in the different drug polymer ratio.
Conclusion: Among them cilnidipine: HPMC: poloxamer 188 shows better solubility and also different physical characterization test like DSC and XRD.
After selection of best ternary solid dispersion fast dissolving tablets of cilnidipine were prepared using direct compration method via using different super disintegrant.
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