Typology of the human organism system adaptation

Transition to personalized medicine requires the systematization of possible scenarios of the human organism individual adaptation to exogenous shocks. Objective: To identify and typology sustainable adaptation options to extreme environmental factors, taking into account individual, genetically determined functional properties of the human organism. As the object of the study, 146 people of both sexes were involved, 18-23 years of age. The work was performed in accordance with Articles 5, 6 and 7 of "The Universal Declaration on Bioethics and Human Rights" with the informed consent registration. As a result of complex theoretical and experimental researches the typology of the human organism system adaptation to extreme exogenous influences is designed. At the same time, stable combinations of functional properties phenotypic manifestations for individuals with high, medium and low level of general non-specific reactivity are systematized. Revealed expressed specific manifestations of the variation pulsometry main indicators depending on the individual level of general non-specific reactivity of an organism, where the prevalence of the sympathetic component of the autonomic nervous system is characteristic for people with high reactivity level and parasympathetic – for individuals with a low reactivity level. It was determined that an emergency exercise stress in individuals with a high level of general non-specific reactivity is a risk factor for sympathicotonia that gives them increased stress reactivity. Taken studies have proved the feasibility of separation of three types of the adaptation process. 1. The syntoxic process, which is typical for low level of general non-specific reactivity. 2. An integrated process inherent to the medium level of reactivity. 3. Catatoxic process, which is typical for a high level of general non-specific reactivity of an organism. The proposed typology is based on the account: the background level of general non-specific reactivity; specificity and speed of adaptation development; vegetative balance; dynamics of nociceptive sensitivity; psycho-emotional state of a person. Using the developed typology allows to individualize an assessment, forecasting and correction of the functional organism state that will provide personalization of health-support a person in high ambient load.