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Antidiabetic and Antidyslipidemic Effects of Artemisia mesatlantica, an Endemic Plant from Morocco
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Aims:
The study aimed to assess the antihyperglycemic and antidyslipidemic activities of
Artemisia mesatlantica.
Background:
Artemisia mesatlantica is an endemic plant of Morocco used in traditional medicine
as an alternative treatment for diabetes.
Objective:
The study was designed to examine the antihyperglycemic and antidyslipidemicability of
aqueous extract of Artemisia mesatlantica (AMAE) in experimental animal models.
Methods:
The effect of the single and repeated oral administration (7 days of treatment) of AMAE
(60 mg/kg) on blood glucose and lipid profile were assessed in normal and streptozotocin-induced
diabetic rats. Furthermore, to confirm the antidyslipidemic effect of Artemisia mesatlantica, a model
of hyperlipidemia induced by tyloxapol (Triton WR-1339) in rats was used.
Results:
The AMAE (60 mg/kg) was able to significantly reduce glycaemia, improve lipid profile
and increase hepatic glycogen content in STZ-induced diabetic rats. In addition, pretreatment of rats
for 7 consecutive days with an aqueous extract of Artemisia mesatlantica (600 mg/kg) prior to tyloxapol
injection prevented increases in plasma levels of total cholesterol, triglycerides and LDL-c.
Conclusion:
From these observed results, it can be deduced that Artemisia mesatlantica possesses
remarkable antidiabetic and antihyperlipidemic properties.
Bentham Science Publishers Ltd.
Title: Antidiabetic and Antidyslipidemic Effects of Artemisia mesatlantica, an
Endemic Plant from Morocco
Description:
Aims:
The study aimed to assess the antihyperglycemic and antidyslipidemic activities of
Artemisia mesatlantica.
Background:
Artemisia mesatlantica is an endemic plant of Morocco used in traditional medicine
as an alternative treatment for diabetes.
Objective:
The study was designed to examine the antihyperglycemic and antidyslipidemicability of
aqueous extract of Artemisia mesatlantica (AMAE) in experimental animal models.
Methods:
The effect of the single and repeated oral administration (7 days of treatment) of AMAE
(60 mg/kg) on blood glucose and lipid profile were assessed in normal and streptozotocin-induced
diabetic rats.
Furthermore, to confirm the antidyslipidemic effect of Artemisia mesatlantica, a model
of hyperlipidemia induced by tyloxapol (Triton WR-1339) in rats was used.
Results:
The AMAE (60 mg/kg) was able to significantly reduce glycaemia, improve lipid profile
and increase hepatic glycogen content in STZ-induced diabetic rats.
In addition, pretreatment of rats
for 7 consecutive days with an aqueous extract of Artemisia mesatlantica (600 mg/kg) prior to tyloxapol
injection prevented increases in plasma levels of total cholesterol, triglycerides and LDL-c.
Conclusion:
From these observed results, it can be deduced that Artemisia mesatlantica possesses
remarkable antidiabetic and antihyperlipidemic properties.
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