Comparative Evaluation of Two Non-Identical Doses of Intrathecal Nalbuphine Versus Fentanyl in Spinal Anesthesia Block for Lower Abdominal Surgeries

Aims and Objectives: To compare the effectiveness of two non-identical doses of nalbuphine (0.5 and 1 mg) in contrast to fentanyl (25μg) as adjuvant to 0.5% hyperbaric Bupivacaine in terms of. Primary objectives: (i) Time to reach complete sensory level (T10), (ii) Duration of motor block, (iii) Duration of analgesia. Secondary objectives: (i) Hemodynamic parameters, (ii) Complications/ side effects. Material and Methods: It is a double-blind randomised control trial. (i) Group F receives 12.5 mg (2.5 ml of 0.5% hyperbaric Bupivacaine) +25 ug Fentanyl (0.5 ml). (ii) Group NL receive 12.5 mg (2.5 ml of 0.5% hyperbaric Bupivacaine) + 0.5 mg Nalbuphine (0.5 ml). (iii) Group NH receive 12.5 mg (2.5 ml of 0.5% hyperbaric Bupivacaine) + 1 mg Nalbuphine (0.5 ml). Results: Demographic particulars and surgical properties were identical in both groups. (i) The time to reach complete sensory level (p<0.001), duration of motor block (p<0.001), the duration of analgesia (p<0.001) were significantly shorter in NL than F and NH groups. (ii) Hemodynamic parameters like HR, SBP, and DBP were lower in group NL. Conclusion: Nalbuphine in 0.5 mg added as an adjuvant to Bupivacaine intrathecally was safe and superior when compared with that of Bupivacaine with Fentanyl and 1 mg of Nalbuphine.