Anti-inflammatory and antibacterial properties of insulin leaves (Tithonia diversifolia) for Periodontitis

Introduction: Periodontal disease or disorders can arise from disruption of homeostasis in the periodontal tissue. Ninety percent of people worldwide suffer from periodontal disease, making it the most common dental disease. Periodontitis may increase the rate of mortality and morbidity significantly. Prevention strategies can be carried out with alternative materials. The use of Tithonia diversifolia or insulin leaves has been practiced folklorically by different ethnic groups without scientific evidence, especially for the treatment of conditions related with pain and inflammation. Methods: The search of literature is conducted through PubMed, Cochrane, the Web of Science, and Google Scholar using keywords for the role of insulin leaf extract (Tithonia diversifolia) as anti-inflammatory and antibacterial for periodontitis. Journal published at least five years ago is acquired. The journal covered the topics of various risk factors for Varicella. The criteria for this study are national and international accredited journals by Scopus and non-Scopus. Results: Of the 15 articles reviewed, it is known that there is a role for insulin leaf extract (Tithonia diversifolia) in the treatment and prevention of periodontitis. Conclusion: From the literature review article obtained, there are several roles of insulin leaf extract (Tithonia diversifolia) in the treatment and prevention of periodontitis with anti-inflammatory and antibacterial mechanisms. Using insulin leaves as mouthrinse can also improve oral health and reduce tooth decay.