Elevated serum NLR and PLR are associated with a higher risk of atherosclerotic renal stenosis

Abstract There is still a lack of effective non-invasive diagnosis of atherosclerotic renal stenosis. The aim of this study was to investigate the association of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) with atherosclerotic renal artery stenosis (ARAS). Data of a total of 1062 patients (362 ARAS, 664 non-ARAS) were collected. Logistic regression analysis and receiver operating characteristic curve analysis was used to analyze the collected patient data. NLR and PLR levels were significantly increased in ARAS group compared with non-ARAS group (p < 0.05). Correlation analysis showed that both NLR and PLR were positively correlated with ARAS (r = 0.199, r = 0.251, p < 0.05), and only NLR was positively correlated with the degree of stenosis of ARAS (r = 0.152, p < 0.05). Multivariate logistic regression showed that NLR (OR = 1.203, 95%CI = 1.023 ~ 1.046, P = 0.025) and PLR (OR = 1.011, 95%CI = 1.003 ~ 1.019, P = 0.004) were independent risk factors for ARAS. The ROC curve indicated that the diagnostic value of NLR and PLR were (AUC = 0.653, P < 0.001; AUC = 0.62, P < 0.001). In conclusion, elevated levels of NLR and PLR are associated with an increased risk of developing ARAS. NLR and PLR have the potential to be a means of diagnosing ARSA.