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Screening of Punica granatum Peel Extracts for Antioxidant and Anticancer Activity Against Skin Cancer
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Punica granatum is a rich source of bioactive compounds exhibiting diverse pharmacological properties. In the
present study, crude extracts obtained from pomegranate peel (PPE) were phytochemically characterized and
evaluated for their antioxidant and anticancer potential against skin cancer. The phytochemical composition of
the extracts was analyzed using Thin Layer Chromatography (TLC), High-Performance Thin Layer
Chromatography (HPTLC), and High-Performance Liquid Chromatography (HPLC) techniques.
The antioxidant potential of the extracts was assessed using standard in vitro assays, demonstrating significant
free radical scavenging activity, particularly in the ethanolic peel extract. The in vitro cytotoxic activity was
further evaluated against the A431 human skin cancer cell line. Among the tested extracts, the ethanolic extract
exhibited pronounced cytotoxic effects, with a lower IC₅₀ value, indicating higher efficacy.
HPLC analysis confirmed the presence of key bioactive compounds, including ellagic acid, which is well-known
for its antioxidant and anticancer properties. Overall, the findings suggest that the ethanolic extract of Punica
granatum peel possesses potent antioxidant and anticancer activities, highlighting its potential for therapeutic and
industrial applications.
Dr. Yashwant Research Labs Pvt. Ltd.
Title: Screening of Punica granatum Peel Extracts for Antioxidant and Anticancer Activity Against Skin Cancer
Description:
Punica granatum is a rich source of bioactive compounds exhibiting diverse pharmacological properties.
In the
present study, crude extracts obtained from pomegranate peel (PPE) were phytochemically characterized and
evaluated for their antioxidant and anticancer potential against skin cancer.
The phytochemical composition of
the extracts was analyzed using Thin Layer Chromatography (TLC), High-Performance Thin Layer
Chromatography (HPTLC), and High-Performance Liquid Chromatography (HPLC) techniques.
The antioxidant potential of the extracts was assessed using standard in vitro assays, demonstrating significant
free radical scavenging activity, particularly in the ethanolic peel extract.
The in vitro cytotoxic activity was
further evaluated against the A431 human skin cancer cell line.
Among the tested extracts, the ethanolic extract
exhibited pronounced cytotoxic effects, with a lower IC₅₀ value, indicating higher efficacy.
HPLC analysis confirmed the presence of key bioactive compounds, including ellagic acid, which is well-known
for its antioxidant and anticancer properties.
Overall, the findings suggest that the ethanolic extract of Punica
granatum peel possesses potent antioxidant and anticancer activities, highlighting its potential for therapeutic and
industrial applications.
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