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Neuroleptic-Induced Catatonia or a Mild Form of Neuroleptic Malignant Syndrome?

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Neuroleptic-induced catatonia (NIC) and milder neuroleptic malignant syndrome (NMS) share parkinsonian features, catatonic symptoms, mild fever, and have been described in patients receiving antipsychotic agents. We report the case of a patient with a schizophreniform disorder and a mild mental retardation who developed a condition which can be diagnosed either as NIC or as a mild form of NMS and has been treated successfully with a combination of amantadine (600 mg/day) and diazepam (30 mg/day). The overlapping between NIC and mild NMS cases might lead to an overestimation of the incidence of current NMS and reinforces the view of the existence of a ‘neuroleptic toxicity spectrum’.

S. Karger AG

V.P. Kontaxakis N.M. Vaidakis G.N. Christodoulou H.C. Valergaki

Neuropsychobiology

Title: Neuroleptic-Induced Catatonia or a Mild Form of Neuroleptic Malignant Syndrome?

Description:

Neuroleptic-induced catatonia (NIC) and milder neuroleptic malignant syndrome (NMS) share parkinsonian features, catatonic symptoms, mild fever, and have been described in patients receiving antipsychotic agents.

We report the case of a patient with a schizophreniform disorder and a mild mental retardation who developed a condition which can be diagnosed either as NIC or as a mild form of NMS and has been treated successfully with a combination of amantadine (600 mg/day) and diazepam (30 mg/day).

The overlapping between NIC and mild NMS cases might lead to an overestimation of the incidence of current NMS and reinforces the view of the existence of a ‘neuroleptic toxicity spectrum’.

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