A CREAM CONTAINING LINOLEIC ACID, 5%DEXPANTHENOL AND CERAMIDE IN THE TREATMENT OF ATOPIC DERMATITIS v1

Abstract Introduction: Nowadays, moisturizers contain non-steroidal anti-inflammatory agents help for treatment of atopic dermatitis (AD). Defensil (black currant seed oil, sunflower oil, and balloon vine), a new anti-inflammatory, obtained from plant extracts remain had a few study for AD. Objective: To compare the effectiveness of moisturizer containing 3% Defensil, 5% dexpanthenol and ceramide (LDC) with 5% urea cream in treatment of childhood AD. Methods: Thirty-eight patients with diagnosis of atopic dermatitis by UK working party’s criteria were recruited in randomized, controlled, double-blinded 4-week study. The patients were received with twice-daily application of LDC cream on one side of the body and 5% urea cream on the opposite side. The clinical severity was assessed by modified scoring of atopic dermatitis (SCORAD). Median time to remission wasanalyzed by survival analysis. Results: Thirty-seven out of 38 patients accomplished the protocol. The clinical modified SCORAD significantly improved from baseline in both groups (p <0.001) after 2 and 4 weeks. Furthermore, LDC group significantly reduced severity of disease better than 5% urea group (P=0.043). The mean difference SCORAD scores were -13.83 (± 1.83) and -13.04 (± 3.22) respectively. Stratum corneum hydration (SCH) was enhanced from baseline in both group (p<0.001) but no statistically significant difference between both groups. Median time to remission had no statistically significant difference (P=0.703). Conclusion:The effectiveness of LDC cream is better than 5% urea cream for improving clinical atopic dermatitis.It was suggested that moisturizer containing LDC could be used for the treatment of mild-to-moderate childhood atopic dermatitis.