GW24-e1187 The baseline of brachial artery diameter would be the predictor of atherosclerosis

Objectives To investigate the baseline of the brachial artery diameter (BAD) whether would be the predictor of atherosclerosis, and build up BAD risk category standard for both gender in future. Methods Between January 2009 and March 2012, 1083 subjects (including 544 males and 539 females) aged from 30 to 80 years old were studied. According to the Framingham risk score, subjects were divided into three groups, low-risk, middle risk and high-risk group respectively. We measured traditional cardiovascular risk factors, laboratory and vascular parameters, BAD, carotid artery intima media thickness (IMT) and brachial artery endothelial dependent dialation (FMD). Results IMT and BAD both increased with the Framingham risk level increasing in both gender. In high-risk groups, BAD were significantly larger than low and middle risk groups and BAD of middle risk groups were larger than low risk groups. In males, they were respectively (low risk: 3.93 ± 0.51; mid-risk: 4.01 ± 0.59, high risk: 4.11 ± 0.52, P = 0.007). In females, they were respectively (low risk : 3.19 ± 0.44; mid-risk: 3.44 ± 0.48, high risk: 3.62 ± 0.53, P < 0.001). For IMT and BAD, there were significantly differences in three-risk groups in both gender. Carotid artery IMT and BAD increased with the Framingham risk level increasing and Univariate analysis showed that there were significant positive correlations between IMT, BAD and FRS. They were respectively (RIMT = 0.437, RBAD = 0.304, P < 0.001. Conclusions IMT and BAD both increased with the Framingham risk level increasing in both gender. BAD would be the predictor of atherosclerosis as well as IMT.