The association of follicle stimulating hormone with the level of triglycerides during postmenopausal periods in the prediction of cardiovascular diseases. A correlation meta-analysis (Preprint)

BACKGROUND Background: Different studies conducted by different researchers about the metabolism of lipids among postmenopausal women is related with the level of estrogen but recent evidence has provided evidence for extragonadal effects of FSH on lipids. However, the findings are still unclear and inconsistent that necessitated systematic review and metanalysis OBJECTIVE Objective: To determine the effect of follicle stimulating hormone on the level of triglycerides among postmenopausal women METHODS Method: PubMed, Cochran library, Scopus and Google scholar was used to search literatures systematically and a total of 747 papers published between 1998-2021 were retrieved. Studies with postmenopausal women as study participants and had reported either of the correlation coefficient or beta coefficient of triglycerides were included. The pooled estimated correlation coefficient between triglycerides and follicle stimulating hormone was computed using random effect model. Heterogeneity test was conducted by using forest plot. Publication bias was checked using eggers test. Meta-regression and subgroup analysis was done to find out the responsible modifiers for the overall correlation coefficient. RESULTS Result: A total of 11 papers ,8 cross-sectional,2 retrospective cohort and 1 prospective cohort were included in this systematic review and meta-analysis. The pooled correlation coefficient was calculated for triglycerides and follicle stimulating hormone and positive association were observed between triglycerides and follicle stimulating hormone. CONCLUSIONS Conclusion The levels of FSH positively associated with TG and but the relationship was not significant.