DEXMEDETOMIDINE/ FENTANYL INFUSION IN OPEN CARDIAC SURGERIES

Background: patients of open heart surgeries are now a days extudated early for fasttraking & improve patient outcome. Aims and Objectives: To compare the efficacy of dexmedetomidine/ fentanyl for sedoanalgesia& time ro extubation in post-operative adult cardiac surgical patients. Methods: A prospective randomized double-blind study involving 60 adult patients undergoing open heart surgery were divided into two groups, each involving 30 patients. One group received fentanyl at 1 µg/kg/h (Group A) and the other received dexmedetomidine at 0.5 µg/kg/h (Group B) for post-operative sedation with intermittent rescue dose of fentanyl 0.5 µg/kg bolus in either group as rescue analgesia as per requirement. The efficacy of sedation was assessed using the Ramsay sedation score. The time taken for extubation from the stoppage of infusion was noted.Patients were enrolled in two Randomised groups of 30 patients each. With occasional rescue doses of fentanyl 0.5 g/kg bolus in either group as needed, one group (Group A) received fentanyl at 1 g/kg/h and the other (Group B) received dexmedetomidine at 0.5 g/kg/h for postoperative sedation. The Ramsay sedation score was used to evaluate the effectiveness of the sedation. It was noticed how long it took to extubate once the infusion was stopped. Results: Haemodynamic parameters between the two groups were comparable. Sedation scores between fentanyl and dexmedetomidine groups were comparable. Average time (in minutes) required for extubation was 100.04 (±43.6 SD) in the dexmedetomidine group compared with 159.4 (±93.3 SD) in the fentanyl group. The difference in mean time for extubation was statistically significant. Conclusions: As compare to fentanyl , Dexmedetomidine facilitates adequate sedation for mechanical ventilation and also provide early extubation.