Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
N-Heterocyclic Carbene-Catalysed Mukaiyama–Michael Reaction and Mukaiyama Aldol/Mukaiyama–Michael Three-Component Coupling Reaction
View through CrossRef
An N-heterocyclic carbene-catalysed Mukaiyama–Michael addition between several trimethylsilyl (TMS) enol ethers and chalcone derivatives has been discovered. In addition, a related reaction cascade involving dehydrative Mukaiyama aldol followed by a Mukaiyama–Michael addition process has been developed. The later reaction can also be achieved as a three-component coupling reaction. The enantioselective variant of these reactions has been examined with homochiral catalysts. Though these catalysts were active, they fail to achieve enantioinduction.
Title: N-Heterocyclic Carbene-Catalysed Mukaiyama–Michael Reaction and Mukaiyama Aldol/Mukaiyama–Michael Three-Component Coupling Reaction
Description:
An N-heterocyclic carbene-catalysed Mukaiyama–Michael addition between several trimethylsilyl (TMS) enol ethers and chalcone derivatives has been discovered.
In addition, a related reaction cascade involving dehydrative Mukaiyama aldol followed by a Mukaiyama–Michael addition process has been developed.
The later reaction can also be achieved as a three-component coupling reaction.
The enantioselective variant of these reactions has been examined with homochiral catalysts.
Though these catalysts were active, they fail to achieve enantioinduction.
Related Results
The Directed Aldol Reaction
The Directed Aldol Reaction
Abstract
The aldol reaction, usually carried out in protic solvents with base or acid as the catalyst, is one of the most versatile methods in organic synthesis. By appli...
The interaction between neural populations: Additive versus diffusive coupling
The interaction between neural populations: Additive versus diffusive coupling
AbstractModels of networks of populations of neurons commonly assume that the interactions between neural populations are via additive or diffusive coupling. When using the additiv...
The Tishchenko Reaction
The Tishchenko Reaction
AbstractAldehydes may be dimerized to symmetric esters via the Tishchenko reaction. This process is traditionally catalyzed by aluminum alkoxides, but a wide variety of different m...
Intramolecular Alkynylogous Mukaiyama Aldol Reaction Starting from Bicyclic Alkanones Tethered to Alkynyl Esters: Formal Total Synthesis of (±)‐Hamigeran B
Intramolecular Alkynylogous Mukaiyama Aldol Reaction Starting from Bicyclic Alkanones Tethered to Alkynyl Esters: Formal Total Synthesis of (±)‐Hamigeran B
AbstractSelecting the ring: tert‐Butyldimethylsilyltriflate (TBSOTf)/NEt3 treatment of alkynyl esters tethered to bicycloalkanones leads to the formation of tricyclic allenoates wi...
Evaluation of TH multi-scale coupling methods in BEPU analysis
Evaluation of TH multi-scale coupling methods in BEPU analysis
The combined use of thermal-hydraulics system with sub-channel codes (TH-TH coupling) in transient analysis provides an integrated tool with the capability of modelling in detail b...
Masked N‐Heterocyclic Carbene‐Catalyzed Alkylation of Phenols with Organic Carbonates
Masked N‐Heterocyclic Carbene‐Catalyzed Alkylation of Phenols with Organic Carbonates
AbstractAn easily prepared masked N‐heterocyclic carbene, 1,3‐dimethylimidazolium‐2‐carboxylate (DMI‐CO2), was investigated as a “green” and inexpensive organocatalyst for the alky...
Triplet carbene that is isolated as a solid and bottled for months
Triplet carbene that is isolated as a solid and bottled for months
AbstractOur efforts to isolate a triplet carbene as a solid so that one can “see” and keep it in a bottle have resulted in the most persistent species, namely, bis[10‐(4‐tert‐butyl...
ChemInform Abstract: The Mukaiyama Aldol and Mukaiyama—Michael Reactions Promoted by Commercially Available Molecular Sieves.
ChemInform Abstract: The Mukaiyama Aldol and Mukaiyama—Michael Reactions Promoted by Commercially Available Molecular Sieves.
AbstractThe Mukaiyama aldol reactions of aldehydes (I) and (IV) with silyl ketene acetals or silyl enol ethers (II) proceed smoothly in the presence of pulverized mol....