Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Striking a balance: the Goldilocks effect of CD8α expression on NK cells
View through CrossRef
NK cells are cytotoxic innate immune cells involved in antitumor immunity, and they provide a treatment option for patients with acute myeloid leukemia (AML). In this issue of the
JCI
, Cubitt et al. investigated the role of CD8α, a coreceptor present on approximately 40% of human NK cells. IL-15 stimulation of CD8α
–
NK cells induced CD8α expression via the RUNX3 transcription factor, driving formation of a unique induced CD8α (iCD8α
+
) population. iCD8α
+
NK cells displayed higher proliferation, metabolic activity, and antitumor cytotoxic function compared with preexisting CD8α
+
and CD8α
–
subsets. Therefore, CD8α expression can be used to define a potential dynamic spectrum of NK cell expansion and function. Because these cells exhibit enhanced tumor control, they may be used to improve in NK cell therapies for patients with AML.
American Society for Clinical Investigation
Title: Striking a balance: the Goldilocks effect of CD8α expression on NK cells
Description:
NK cells are cytotoxic innate immune cells involved in antitumor immunity, and they provide a treatment option for patients with acute myeloid leukemia (AML).
In this issue of the
JCI
, Cubitt et al.
investigated the role of CD8α, a coreceptor present on approximately 40% of human NK cells.
IL-15 stimulation of CD8α
–
NK cells induced CD8α expression via the RUNX3 transcription factor, driving formation of a unique induced CD8α (iCD8α
+
) population.
iCD8α
+
NK cells displayed higher proliferation, metabolic activity, and antitumor cytotoxic function compared with preexisting CD8α
+
and CD8α
–
subsets.
Therefore, CD8α expression can be used to define a potential dynamic spectrum of NK cell expansion and function.
Because these cells exhibit enhanced tumor control, they may be used to improve in NK cell therapies for patients with AML.
Related Results
A New Subset of CD103+CD8α+ Dendritic Cells in the Small Intestine Expresses TLR3, TLR7, and TLR9 and Induces Th1 Response and CTL Activity
A New Subset of CD103+CD8α+ Dendritic Cells in the Small Intestine Expresses TLR3, TLR7, and TLR9 and Induces Th1 Response and CTL Activity
Abstract
CD103+ dendritic cells (DCs) are the major conventional DC population in the intestinal lamina propria (LP). Our previous report showed that a small number ...
The Role of Langerin⁺ CD8α⁺ Dendritic Cells in Tumour Immunotherapy
The Role of Langerin⁺ CD8α⁺ Dendritic Cells in Tumour Immunotherapy
<p>The immune system has the potential to selectively target and eliminate tumours cells. However, the induction of an immunosuppressive environment by factors released by tu...
Murine precursors to type 1 conventional dendritic cells induce tumor cytotoxicity and exhibit activated PD-1/PD-L1 pathway
Murine precursors to type 1 conventional dendritic cells induce tumor cytotoxicity and exhibit activated PD-1/PD-L1 pathway
The immediate precursor to murine type 1 conventional DCs (cDC1s) has recently been established and named “pre-cDC1s”. Mature CD8α+ cDC1s are recognized for suppressing graft-versu...
EFFECT OF BCG VACCINATION ON SPLENIC DENDRITIC CELL DEVELOPMENT IN NEONATAL BALB/C MICE
EFFECT OF BCG VACCINATION ON SPLENIC DENDRITIC CELL DEVELOPMENT IN NEONATAL BALB/C MICE
INTRODUCTION: As an immunoregulator, Mycobacterium BCG has the potential to be applied in allergic disease such as asthma prevention in clinic. Previous studies showed that neonata...
[RETRACTED] Guardian Blood Balance –Feel the difference Guardian Blood Balance makes! v1
[RETRACTED] Guardian Blood Balance –Feel the difference Guardian Blood Balance makes! v1
[RETRACTED]Guardian Blood Balance Reviews (Works Or Hoax) Does Guardian Botanicals Blood Balance AU Really Works? Read Updated Report! Diabetes and Hypertension is such a health p...
Thymic Selection of Cytotoxic T Cells Independent of CD8 α-Lck Association
Thymic Selection of Cytotoxic T Cells Independent of CD8 α-Lck Association
The CD8α cytoplasmic domain associates with p56
lck
, a nonreceptor protein-tyrosine kinase. The biological relevance of CD8α-Lc...
Type I IFNs Control Antigen Retention and Survival of CD8α+ Dendritic Cells after Uptake of Tumor Apoptotic Cells Leading to Cross-Priming
Type I IFNs Control Antigen Retention and Survival of CD8α+ Dendritic Cells after Uptake of Tumor Apoptotic Cells Leading to Cross-Priming
Abstract
Cross-presentation is a crucial mechanism for generating CD8 T cell responses against exogenous Ags, such as dead cell-derived Ag, and is mainly fulfilled b...
CD8α+ Dendritic Cells Induce Leukemia-Specific T cell Tolerance
CD8α+ Dendritic Cells Induce Leukemia-Specific T cell Tolerance
Abstract
Antigen presenting cells (APCs) are critical for the acquisition of tumor-derived antigens and the orchestration of anti-tumor T cell responses. Batf3-depen...