Synthesis and Characterization of some New Amic acid and Imides and study the Biological Activity

This study includs the synthesis of some new Amic acid and Imides,starting from the esters [S1] of Terephthalic acid which then converted toits hydrazide [S2] then to amic acid derivatives [S3-S7] and finally withimides [S8-S12]. Preparing of ester [S1] by usual esterification ofterephthalic acid with absolute ethanol in acidic medium, then hasconverted to its hydrazide [S2] by reacting it with hydrazine hydrate. Theamic acid derivatives [S3-S7] have been synthesized by the reaction ofhydrazide [S2] with anhydrides (2,3-dimethyl malic anhydride, 3-nitrophthalic anhydride, hexahydro phthalic anhydride, Diphenic anhydride,tetra Phenyl phthalic anhydride) in diethyl ether. Imides [S8-S12] werealso synthesized by cyclization of amic acids derivatives using aceticacid anhydride and anhydrous sodium acetate. The synthesizedcompounds were identified by spectral methods UV, FT-IR and H1-NMR beside melting point and the purity was determined using (TLC)and some of its physical properties were measured. Some of thesecompounds were tested against four strains of bacteria (E. coli, P.ariginosa, S. aurous and S. pyogenes)