Study of the “structure‐biological activity” relationship in a number of flavonoids of plants of Kazakhstan

The aim of the work was the study of the biological activity of technologically available flavonoid isolated from Salsola collina Pall. and Serratula coronata L. plants growing on the territory of Kazakhstan, as well as some modified derivatives of flavonoid quercetin and crude extracts. The method of acute hypoxia was applied in experiment to determine antioxidant activity of modified flavonoid and plant extracts. The results of in vivo bio screening on antioxidant activity have shown that quercetin and dry extracts of Serratula coronata L., as well as the extracts of Salsola Collina Pall. show remarkable antioxidant activity. It was found that the concentration of malondialdehyde in the brain and liver tissues of laboratory rats, which were preventively treated with flavonoids and extracts, is lower than in the control animals and is close to that of the intact group. Quantitative comparison showed that antioxidant effect is more significant in the case of extract of Serratula coronata L. Explanation of the high antioxidant effect in the studied plant of Serratula species lies in the composition of the extract. Feature of the whole extract of Serratula coronata L is the presence of molecules with a diphenyl structure, which opens up the possibility of participation in the reconstruction of biomembranes, lipid‐sensitive processes.