Role of BMI in PCOS Towards Cardiovascular Risk Factors

Abstract Background: Polycystic ovary syndrome (PCOS) is a prevalent disorder in which blood markers of cardiac disorders have been frequently established. However, the impact of obesity on PCOS is still to be discovered. This study was designed to determine if cardiac disorder in PCOS women may explain by altered BMI and biochemical parameters.Methods: A prospective study was carried out by having 100 samples of obese (50) and non-obese (50) PCOS patients. Blood samples (<5ml) were collected, statistical analysis and correlation of BMI were done with hormonal and lipid profile.Results: On Pearson correlation analysis of BMI with lipid and hormonal profile, cholesterol showed a positive correlation in obese PCOS. Spearman correlation analysis of BMI showed positive significant correlation with testosterone in non-obese PCOS. Obese and non-obese groups were further subdivided into married (obese, non-obese), unmarried (obese and non-obese) groups. Negative correlation with LH in married obese, while none of the significant results had been found in married non-obese. In the case of unmarried obese, testosterone showed negative and estradiol showed a positive correlation in unmarried non-obese.Conclusions: The data from this study concluded that young PCOS women have evidence for altered endocrine functions along with elevated BMI. Furthermore correlation of BMI and testosterone might be one of the major factors of developing adiposity and infertility that further causes cardiac diseases. Lifestyle modifications are also beneficial for lessen the ovarian cysts and promote fertility in pubertal females. However, the evidence is limited and more investigations are still needed.