Synthesis, characterization, and some pharmacological evaluation of 5-Thiocyanatouracil compound

5-Thiocyanotouracil (5-TCU) was prepared in convenient method involved direct reaction of Potassium thiocyanate with 5-Iodouracil in refluxing aqueous solvent to give white crystalline in very good yield and high purity. This compound is important because it is similar in structure to 5-Flourouracil, which is of great importance as anti-cancer drug that is still used today. FT-IR, 1H- NMR, 13C- NMR, and CHN elemental analyses were used to describe the product. Median lethal dose LD50, in vitro antiradical activity and antibacterial effects were done. The results indicated that 5-TCU has relatively high LD50, non-significate antioxidant effect compare with ascorbic acid, and some antibacterial activity.