Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Determination of protective role of selenium against aflatoxin B 1 -induced DNA damage
View through CrossRef
Selenium is an essential mineral for a healthy life. Appropriate doses of it may undertake a protective role in the organism. In this study, the protective role of selenium (Se
4+
) against aflatoxin B
1
(AFB
1
)-induced DNA damage was determined using random amplified polymorphic DNA on two plants including Vicia faba and Zea mays. It was observed that the concentrations of 0.1, 0.2 and 0.4 ppm of AFB
1
have increased polymorphism value, total chlorophyll inhibition rate (IR
c
, %) and total protein IR (IR
p
, %). Unlike protein, chlorophyll contents and genomic template stability were decreased. With the addition of different concentrations (0.8 and 80 ppm) of Se
4+
to the treated samples with AFB
1
, the values return to normal. An 800-ppm concentration of Se
4+
, on the contrary, could not inhibit the toxicity of AFB
1
but caused an increase in toxicity level of AFB
1
/enhanced the toxicity level of AFB
1
. Results suggested that Se
4+
has an antagonistic effect against AFB
1
toxicity and that the degree of antagonistic effect of Se
4+
against AFB
1
was related to its concentration.
Title: Determination of protective role of selenium against aflatoxin B
1
-induced DNA damage
Description:
Selenium is an essential mineral for a healthy life.
Appropriate doses of it may undertake a protective role in the organism.
In this study, the protective role of selenium (Se
4+
) against aflatoxin B
1
(AFB
1
)-induced DNA damage was determined using random amplified polymorphic DNA on two plants including Vicia faba and Zea mays.
It was observed that the concentrations of 0.
1, 0.
2 and 0.
4 ppm of AFB
1
have increased polymorphism value, total chlorophyll inhibition rate (IR
c
, %) and total protein IR (IR
p
, %).
Unlike protein, chlorophyll contents and genomic template stability were decreased.
With the addition of different concentrations (0.
8 and 80 ppm) of Se
4+
to the treated samples with AFB
1
, the values return to normal.
An 800-ppm concentration of Se
4+
, on the contrary, could not inhibit the toxicity of AFB
1
but caused an increase in toxicity level of AFB
1
/enhanced the toxicity level of AFB
1
.
Results suggested that Se
4+
has an antagonistic effect against AFB
1
toxicity and that the degree of antagonistic effect of Se
4+
against AFB
1
was related to its concentration.
Related Results
A New Method for Calculating Selenium Content and Determining Appropriate Selenium Levels in Foods
A New Method for Calculating Selenium Content and Determining Appropriate Selenium Levels in Foods
Calculating the selenium content per 100 kcal, 100 g or 100 mL, or the reference amount customarily consumed (RACC) of food shows the selenium content of some foods inappropriately...
Incidence of mycotoxigenic fungi during processing and storage of bambara groundnut (Vigna subterranea) composite flour
Incidence of mycotoxigenic fungi during processing and storage of bambara groundnut (Vigna subterranea) composite flour
Fungal contamination of food commodities is a global food security challenge that impacts negatively on the health of consumers. Mycotoxins are produced as secondary metabolites by...
Evaluation of selenium bioavailability in natural selenium-rich soil by gradient diffusion film technology and chemical extraction method: a case study in Yanqi Basin, Northwest China
Evaluation of selenium bioavailability in natural selenium-rich soil by gradient diffusion film technology and chemical extraction method: a case study in Yanqi Basin, Northwest China
Abstract
Effective selenium is an important indicator for evaluating the supply capacity of selenium to plants in soil. The chemical extraction method and soil solution met...
Ameliorative effect of nanocurcumin and Saccharomyces cell wall alone and in combination against aflatoxicosis in broilers
Ameliorative effect of nanocurcumin and Saccharomyces cell wall alone and in combination against aflatoxicosis in broilers
Abstract
Background
The adverse effect of aflatoxin in broilers is well known. However, dietary supplementation of Saccharomyces cell wall and/or Na...
Exposure of children 4 to 6 months of age to aflatoxin in Kisumu County, Kenya
Exposure of children 4 to 6 months of age to aflatoxin in Kisumu County, Kenya
Contamination of foods by aflatoxins is a global health problem in both developed and developing countries. Exposure to the toxin s is associated with a range of effects on health ...
Aflatoxin exposure among children of age 12–59 Months in Butajira District, South-Central Ethiopia: a community based cross-sectional study
Aflatoxin exposure among children of age 12–59 Months in Butajira District, South-Central Ethiopia: a community based cross-sectional study
Abstract
Background
The continued provision of safe food, free of aflatoxin remains a huge challenge in developing countries. Despite several favour...
Aflatoxin Exposure among Children of age 12-59 Months in Butajira District, South-Central Ethiopia: a community based cross-sectional study
Aflatoxin Exposure among Children of age 12-59 Months in Butajira District, South-Central Ethiopia: a community based cross-sectional study
Abstract
Background
The continued provision of safe food, free of aflatoxin remains a huge challenge in developing countries. Despite several favourable climatic condition...
Genome wide hypomethylation and youth-associated DNA gap reduction promoting DNA damage and senescence-associated pathogenesis
Genome wide hypomethylation and youth-associated DNA gap reduction promoting DNA damage and senescence-associated pathogenesis
Abstract
Background: Age-associated epigenetic alteration is the underlying cause of DNA damage in aging cells. Two types of youth-associated DNA-protection epigenetic mark...