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Delta-opioid receptor–mediated neural protection and regeneration
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The delta-opioid receptor was previously viewed as a mediator in pain regulation. Recent data shed light on its specific role in neural protection and regeneration. An up-regulation of delta-opioid receptor expression and/or activity protects neuronal cells/tissues against various injuries and promotes neural regeneration. This review focuses on these new findings and the underlying mechanisms. In particular, we summarize the following key points: (1) the role of delta-opioid receptor in neuroprotection across various models and conditions; (2) the mechanisms of delta-opioid receptor neuroprotection against acute injury; (3) the neuroprotective mechanisms of delta-opioid receptor during prolonged injury; (4) delta-opioid receptor protection against ischemic and degenerative brain diseases and the underlying mechanisms; and (5) the regulation of delta-opioid receptor in neural regeneration. This article aims to provide an overview of delta-opioid receptor-mediated neural protection and regeneration, as well as its potential in treating neurological diseases.
Ovid Technologies (Wolters Kluwer Health)
Title: Delta-opioid receptor–mediated neural protection and regeneration
Description:
The delta-opioid receptor was previously viewed as a mediator in pain regulation.
Recent data shed light on its specific role in neural protection and regeneration.
An up-regulation of delta-opioid receptor expression and/or activity protects neuronal cells/tissues against various injuries and promotes neural regeneration.
This review focuses on these new findings and the underlying mechanisms.
In particular, we summarize the following key points: (1) the role of delta-opioid receptor in neuroprotection across various models and conditions; (2) the mechanisms of delta-opioid receptor neuroprotection against acute injury; (3) the neuroprotective mechanisms of delta-opioid receptor during prolonged injury; (4) delta-opioid receptor protection against ischemic and degenerative brain diseases and the underlying mechanisms; and (5) the regulation of delta-opioid receptor in neural regeneration.
This article aims to provide an overview of delta-opioid receptor-mediated neural protection and regeneration, as well as its potential in treating neurological diseases.
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