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Niflumic acid-collagen delivery systems used as anti-inflammatory drugs and analgesics in dentistry
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Collagen sponges are known to be safe and well-characterized supports for drug delivery systems. The aim of this study was to prepare, characterize and test drug delivery systems that contain collagen as support and niflumic acid as a drug. Type-I collagen and niflumic acid gels were cross-linked with different concentrations of glutaraldehyde and then freeze-dried in order to obtain collagen matrices (spongious form). The physical-chemical properties were assessed by infrared spectroscopy (FTIR) and morphological properties were evaluated by water absorption. Niflumic acid release from cross-linked collagen spongious forms was also investigated and the kinetic mechanism was discussed.
Title: Niflumic acid-collagen delivery systems used as anti-inflammatory drugs and analgesics in dentistry
Description:
Collagen sponges are known to be safe and well-characterized supports for drug delivery systems.
The aim of this study was to prepare, characterize and test drug delivery systems that contain collagen as support and niflumic acid as a drug.
Type-I collagen and niflumic acid gels were cross-linked with different concentrations of glutaraldehyde and then freeze-dried in order to obtain collagen matrices (spongious form).
The physical-chemical properties were assessed by infrared spectroscopy (FTIR) and morphological properties were evaluated by water absorption.
Niflumic acid release from cross-linked collagen spongious forms was also investigated and the kinetic mechanism was discussed.
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