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Treatable Bacterial Infections Are Underrecognized Causes of Fever in Ethiopian Children
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Febrile illnesses remain a major cause of morbidity and mortality in resource-poor countries, but too often, tests are not available to determine the causes, leading to misdiagnosis and inappropriate treatment. To determine the cause of febrile illnesses, we recovered the malaria smears from 102 children presenting with fever to Soddo Christian Hospital in Wolaitta Soddo, Ethiopia. DNA was isolated from the smears and evaluated by real-time polymerase chain reaction. We identified pathogen DNA with probes for
Plasmodium
spp.,
Streptococcus pneumoniae
,
Rickettsia
spp.,
Salmonella
spp., and
Borrelia
spp. Overall, we showed that it is possible to isolate high-quality DNA and identify treatable pathogens from malaria blood smears. Furthermore, our data showed that bacterial pathogens (especially
Pneumococcus
,
Rickettsia
spp., and
Borrelia
spp.) are common and frequently unrecognized but treatable causes of febrile illnesses in Ethiopian children.
American Society of Tropical Medicine and Hygiene
Title: Treatable Bacterial Infections Are Underrecognized Causes of Fever in Ethiopian Children
Description:
Febrile illnesses remain a major cause of morbidity and mortality in resource-poor countries, but too often, tests are not available to determine the causes, leading to misdiagnosis and inappropriate treatment.
To determine the cause of febrile illnesses, we recovered the malaria smears from 102 children presenting with fever to Soddo Christian Hospital in Wolaitta Soddo, Ethiopia.
DNA was isolated from the smears and evaluated by real-time polymerase chain reaction.
We identified pathogen DNA with probes for
Plasmodium
spp.
,
Streptococcus pneumoniae
,
Rickettsia
spp.
,
Salmonella
spp.
, and
Borrelia
spp.
Overall, we showed that it is possible to isolate high-quality DNA and identify treatable pathogens from malaria blood smears.
Furthermore, our data showed that bacterial pathogens (especially
Pneumococcus
,
Rickettsia
spp.
, and
Borrelia
spp.
) are common and frequently unrecognized but treatable causes of febrile illnesses in Ethiopian children.
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