NEPHROPROTECTIVE POTENTIAL OF BISKHAPRA (TRIANTHEMA PORTULACASTRUM LINN.) LEAVES EXTRACT IN CISPLATIN-INDUCED ACUTE KIDNEY INJURY IN WISTAR ALBINO RATS: AN EXPERIMENTAL STUDY

The kidneys are essential organs responsible for excretion and maintaining homeostasis.Acute kidney injury(AKI)is a severe clinical condition characterized by sudden deterioration in renal function, often resulting from nephrotoxic agents such as cisplatin, which is widely used in chemotherapy. Cisplatin-induced nephrotoxicity is a significant clinical limitation, with oxidative stress, inflammation, and tubular damage being the primary mechanisms involved. The present study aimed to evaluate the nephroprotective potential of aqueous and hydro-alcoholic extracts of Biskhapra (Trianthema portulacastrum Linn.) leaves in a cisplatin-induced AKI rat model.The experimental study involved forty healthy Wistar albino rats (150–200 g) divided into five groups (n=8). Group I served as plain control, receiving distilled water; Group II was the negative control, receiving a single intraperitoneal injection of cisplatin (5 mg/kg b.w.); Group III was treated with cisplatin plus standard nephroprotective agent silymarin (50 mg/kg p.o.); Group IV and Group V received cisplatin plus aqueous and hydro-alcoholic extracts of Biskhapra leaves (450 mg/kg p.o.), respectively, for 14 days.Renal function was assessed by serum creatinine, blood urea, blood urea nitrogen (BUN), serum uric acid, total serum protein, serum albumin, and serum globulin.