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Immunohistochemical Expression of Myeloid Differentiation Adaptor Protein-88(MYD-88 )and Toll like Receptor (TLR-4) in Human Leiomyomas
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Leiomyomas are the most common benign tumor of the female reproductive tract. The aim of this study wasto explore the role of TLR4/ MYD-88signaling pathway in the pathogenesis of leiomyomas. Benign natureand smooth muscle origination of leiomyomas was easily documented via histological examination, in thiscross-sectional study of 20 conventional leiomyomas cases TLR4/ MYD-88 antibody status was positive in90% for TLR-4 and in 95% for MYD-88 of leiomyomas. Leiomyomas were stained with TLR4/ MYD-88marker more than those in normal myometrium cases (P<0.001). In conclusion leiomyomas growth may beassociated with TLR4 and MyD88 expression
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Title: Immunohistochemical Expression of Myeloid Differentiation Adaptor Protein-88(MYD-88 )and Toll like Receptor (TLR-4) in Human Leiomyomas
Description:
Leiomyomas are the most common benign tumor of the female reproductive tract.
The aim of this study wasto explore the role of TLR4/ MYD-88signaling pathway in the pathogenesis of leiomyomas.
Benign natureand smooth muscle origination of leiomyomas was easily documented via histological examination, in thiscross-sectional study of 20 conventional leiomyomas cases TLR4/ MYD-88 antibody status was positive in90% for TLR-4 and in 95% for MYD-88 of leiomyomas.
Leiomyomas were stained with TLR4/ MYD-88marker more than those in normal myometrium cases (P<0.
001).
In conclusion leiomyomas growth may beassociated with TLR4 and MyD88 expression.
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