The Influence of Dahlia Tubers Extract (Dahlia Variabilis) on Diabetic in Rats

Background: Diabetes mellitus is a chronic metabolic problem disease defined by hyperglycemia that is recognized as a silent killer and the mother of the disease, causing complications and endangering health. Inulin is a natural fiber found in dahlia tubers (dahlia variabilis) that functions as a dietary fiber and is suitable for diabetics to consume. The purpose of this study was to see how inulin from dahlia tubers affects blood glucose levels in diabetic rats. Methods: The rats were randomized into five groups at random: normal control, STZ-induced diabetic, STZ-induced diabetic with inulin (0.5 mg/g BW), STZ-induced diabetic with inulin (1.0 mg/g BW), and STZ-induced diabetes (1.5 mg/g BW). Before and after treatment, rats' blood glucose levels were assessed. Results: This study discovered that inulin doses of 0.5mg/g BW, 1.0mg/g BW, and 1.5mg/g BW lowered rats' fasting blood glucose levels. When compared to the other treatment groups, the rats administered inulin at a dose of 1.5mg/g BW demonstrated the most significant drop in fasting blood glucose levels (p<0.05). The reduction in fasting blood glucose levels of rats in the treatment group was accompanied by a substantial reduction in body weight compared to the normal control group (p<0.05) at the end of the treatment. Conclusion: From the study, it was found that administration of inulin from dahlia tuber extract at a dose of 1.5 mg/g BW could significantly reduce blood glucose levels and body weight in diabetic rats.