Effects of combined leaf extracts of Vernonia amygdalina and Ocimum gratissimum on biochemical parameters of sodium arsenite induced toxicity in albino Wister rat

This study was carried out to examine the effect of different leaf extract treatment on Sodium Arsenite toxicity in albino Wister rat model. Twenty-five (25) rats weighing between 120-270 g were used in this experiment and randomly divided into five (5) groups containing five rats each. Group 1 animals served as control and was administered placebo, while group 2 was induced with only sodium arsenite, 3 and 4 were both induced with sodium arsenite sand treated with Ocimum gratissimum ethanoic extract and Vernonia amygalina ethanoic extract respectively. Group 5 received concomitant administration of both extract after induction for 14 days. All drugs and extract administration were dose dependent on kilogram body weight using a cannula attached to a syringe. The result showed a significant elevation of sodium arsenite in group 2 serving as a biochemical marker defining sodium arsenide toxicity to living rat model tissue when compared to group 1. Group 5 showed no significant (p<0.05) difference when compared to group 1. Thus, showing an overall improvement in the effect of combined administration of the extract in the management of sodium arsenite level in sodium asenite induced toxicity when compared to groups 3 and 4 which may be associated with the phytochemicals present in both herbs.