In Vitro Evaluation of the Anthelmintic Activity on the Aqueous and Alcoholic Bark Extract of Swietenia Macrophylla.

Swietenia macrophylla, a plant from the Meliaceae family, has long been utilized in traditional medicine for its antimicrobial, antiinflammatory, antioxidant, and other beneficial properties. This study aimed to investigate the anthelmintic activity of its bark extract in alcoholic and aqueous solvents using Eisenia andrei. The bark was collected, dried, crushed, and subjected to Soxhlet extraction using water and alcohol as solvents. Different concentrations (10, 20, and 40 mg/ml) of both aqueous and alcoholic extracts were tested for their vermicidal effects, with albendazole used as a reference standard at 20 mg/ml. Phytochemical analysis revealed thepresence of alkaloids, flavonoids, tannins, saponins, and terpenoids in both extracts, which are potentially responsible for the observed anthelmintic activity. The paralysis and death times of Eisenia andrei were recorded for each extract and the reference standard. Statistical analysis showed significant differences between the extracts and the reference, with both alcoholic and aqueous extracts demonstrating dose-dependent vermicide activity. The higher concentration (40 mg/ml) of both extracts exhibited stronger anthelmintic effects. The study identified tannins and triterpenoids in the bark of Swietenia macrophylla as key active componentsresponsible for its potent anthelmintic properties. In conclusion, the 40 mg/ml concentration of both the alcoholic and aqueous extracts exhibited the highest anthelmintic activity. Among these extract the alcoholic extract at 40mg/ml show more potent anthelmintic activity