A Comprehensive Review on Strategies of Topical Niosomes and Their Synergistic Effect for Enhanced Therapeutic Outcomes

The review aims to assess the potential of niosomes—nonionic surfactant-based vesicular systems—as carriers for topical and transdermal drug delivery. Niosomes enable targeted and controlled drug release while minimizing systemic toxicity. The investigation centers on their structure, stability, and capacity to entrap both hydrophilic and lipophilic drugs, as well as their use in managing various dermatological and systemic disorders. Recent studies have examined the formulation of niosomes, particularly highlighting the roles of nonionic surfactants and cholesterol in enhancing the stability and entrapment efficiency of these vesicles. Research on permeability enhancers has been reviewed for their ability to work together to improve drug transport and bioavailability. It also provides a detailed discussion on the use of niosomes in treating various dermatological conditions, as well as their applications in systemic diseases, with a particular focus on co-delivery systems in cancer therapies. Niosomes exhibit efficacy in drug delivery by providing an increase in penetration through the stratum corneum, targeting hydrophilic and lipophilic drugs for dermatological and systemic applications. The Development of niosomal therapy has expanded into immunization, antiinflammatory treatments, and the control of pigmentation. Permeability enhancers further increase their efficacy, bioavailability, and tissue localization. Anticancer treatment using niosomes for codelivery of agents demonstrates synergistic effects with reduced side effects. Niosomes have tremendous potential in advancing topical and transdermal drug delivery, offering controlled, targeted release and improved patient outcomes. With optimized fabrication and comprehensive toxicity evaluation, niosomes can potentially revolutionize topical therapies, making them safer, more effective, and patient-friendly for a range of next-generation treatment options across dermatology and beyond.