WAHO’s collaborative initiatives for Lassa fever prevention and control in the ECOWAS Region

Background Lassa fever is a viral hemorrhagic illness endemic in parts of West Africa, with an estimated 100,000 to 300,000 infections annually, with 5,000 deaths, causing significant morbidity and mortality. The West Africa Health Organization (WAHO), as the specialized health institution of ECOWAS, plays a crucial role in coordinating regional efforts to strengthen health systems, enhance disease surveillance, and improve response capacities to Lassa fever outbreaks. Recognizing the need for a collaborative approach, WAHO established key initiatives to control the spread of the disease and mitigate its impact. Methods WAHO has implemented multiple interventions, including the establishment of the Lassa Fever Coalition Governing Entity (LGE) to steer regional prevention and control strategies. The organization conducts regular cross-border collaborations, capacity-building programs, and knowledge-sharing webinars. Training workshops have been organized on clinical case management and infection prevention and control (IPC) for healthcare workers. Additionally, WAHO collaborates with CEPI and other partners to accelerate Lassa fever vaccine development and clinical trials. Results These initiatives have enhanced regional coordination, with increased participation in webinars, training programs, and the dissemination of knowledge through the Lassa Bulletin. More than 100 health professionals attended the most recent webinar focused on strengthening community-based research. Training-of-trainers sessions have equipped twenty-five healthcare workers with essential skills in clinical management and laboratory diagnosis of Lassa fever. Simulation exercises have bolstered outbreak preparedness and response mechanisms, while data collection efforts have improved disease surveillance. Conclusion WAHO’s Lassa fever initiatives have significantly contributed to strengthening regional preparedness and response. Continued investment in research, training, and surveillance is essential for the sustained control of Lassa fever. Moving forward, WAHO is committed to sustaining collaborative efforts and scaling up vaccine research to mitigate the risk of future outbreaks.