Abstract 1454: IL-4 modulate the tumor microenvironment and response to cancer therapies

Abstract recent findings show that immune cells constitute a large fraction of the tumor microenvironment and modulate tumor progression. Clinical data indicate that chronic inflammation is present at tumor sites and that IL-4 in particular is up-regulated. Thus, we tested whether depletion of IL-4 affected in tumor immunity. Current results demonstrate that administration of neutralizing antibody against IL-4 enhances anti-tumor immunity and improve the response to Taxol-based chemotherapy and CpG ODN immunotherapy. Depletion of IL-4 also alter the tumor microenvironment, reducing the generation of immunosuppressive M2 macrophages and myeloid derived suppressor cells and enhancing tumor specific CTLs. These findings suggest that IL-4 impact anti-tumor immunity and constitute an attractive therapeutic target to reduce immune suppression in the tumor microenvironment and thus enhance the efficacy of cancer therapy. Citation Format: Shuku-ei A. Ito, Hidekazu Shirota, Chikashi Ishioka. IL-4 modulate the tumor microenvironment and response to cancer therapies. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1454.