Changes in Retinal Vascular Bifurcation in Eyes with Myopia

Abstract Objective: To evaluate the effect of myopia on retinal vascular bifurcation. Methods: A cross-sectional study that retrospectively analyzed the fundus photographs and clinical data of 493 people who participated in routine physical examinations in Huadong Sanatorium. One eye of each subject was included in the analysis. Retinal vascular bifurcation measurements were extracted by using a validated computer program. One-way ANOVA and analysis of covariance were performed to compare the measurements across high myopia, low to moderate myopia, and non-myopia groups. Results: The mean age was 41.83 ± 10.43 years and 63.49% were women. The mean spherical equivalent refraction (SER) was -4.59 ± 3.07 D. Ninety-nine (20.08%) eyes met the definition of high myopia (SER ≤ -6.0 D), along with 234 (47.46%) low to moderate myopia (-6.0 D< SER <-0.5 D), and 160 (32.45%) non-myopia (SER ≥ -0.5 D). The differences in the arteriolar branching angle, venular branching coefficient, venular asymmetry ratio, venular angular asymmetry, and venular junctional exponent among the three groups remained significant (p<0.05) after multivariate adjustment. Pairwise comparisons showed arteriolar branching angle and venular angular asymmetry in high myopia were significantly lower than low to moderate myopia (p<0.001, p=0.014 respectively) and non-myopia (p=0.007, p=0.048 respectively). Venular asymmetry ratio and venular branching coefficient in high myopia were significantly higher than low to moderate myopia (p=0.029, p=0.001 respectively) and non-myopia (p=0.041, p=0.043 respectively). There was a significant difference in venular junctional exponent between high myopia and low to moderate myopia (p=0.031). Conclusion: The vascular bifurcation differs in dependence of the myopic refractive error and a significant increase in the difference can be observed in high myopic eyes.