The ultrastructural aspects of neoplastic myoepithelial cell in pleomorphic adenomas of salivary glands

AbstractThe purpose of this study has been to establish the major ultrastructural aspects of the myoepithelial cell and the myoepithelial‐like cells proliferated in the pleomorphic adenomas of salivary glands. Thus, twelve benign pleomorphic adenomas of salivary glands have been studied by electron‐microscopy transmission techniques. Our analysis has proved the proliferation of two major cellular populations, one of ductal type and one of myoepithelial type, which tried to reproduce the tubulo‐acinar cytoarchitecture from the normal salivary glands. We have also noticed the key role of the so‐called ‘modified’ myoepithelial cells from the periphery of the proliferating epithelial units in the genesis of the myxoid and chondromyxoid tumoral stromal areas. All these ultrastructural aspects have explained the great histological diversity of these salivary gland neoplasms as well as the key role of the myoepithelial cell in its histogenesis.