CLINICOHEMATOLOGICAL PROFILE OF PANCYTOPENIA IN A TERTIARY CARE CENTRE

Background: Pancytopenia is a clinical complication of numerous pathological disorders, including infections, hypersplenism, hemolysis, bone marrow inltration, bone marrow suppression and haematological cancers. As a result, it accounts for the majority of drug-induced (chemotherapy) suppression of bone marrow cases. A rapid workup will help to settle many diagnoses since the majority of these individuals rst go to their primary care doctors and may also point to a potentially fatal disease. Aim: The aim of the present study is to analyze the various clinical presentations in pancytopenia and to evaluate various hematological parameters. Materials and Method: The present study was a Cross sectional observational study conducted in department of General Medicine, Sree Mookambika Institute of Medical Sciences, Kulasekharam for a period of one year (January 2022 to December 2022). All patients presenting with pancytopenia who were willing to participate in the present study were included. Patients who got recent blood or blood product transfusion, Patients on chemotherapy/ radiotherapy and patients who were not willing to participate in the study were excluded. A total of 52 patients were included in the present study. Results were analysed using SPSS 20.0 version and the association was tested using Chi square test. Results: Most common presenting complaint among those presented with pancytopenia was tiredness which was seen in 49(94.23%) patients. Pallor was seen in all patients. Aplastic anemia was the most common bone marrow nding 11(31.42%) followed by erythroid hyperplasia 9(25.71%), acute leukemia 6 (17.14%), multiple myeloma 5 (14.28%), megaloblastic anemia3(8.57%) and metastatic tumor 1 (2.85%). Conclusion: Aplastic anemia was the most typical cause of pancytopenia in the current investigation. Pancytopenia can result from a wide range of illnesses, while the likelihood that any one disorder will also result in pancytopenia varies greatly. The degree of the pancytopenia and the type of underlying disease will determine the prognosis.