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Antidiabetic Activity of Peperomia pellucida In Streptozotocin-Induced Diabetic Mice
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Background: Diabetes mellitus is a heterogeneous group of diseases in the form of disorders in the body's metabolism clinically. Peperomia pellucida herbs have phytochemical containing which is antidiabetic potential development. Objectives: This study was conducted to compare the antidiabetic activity of ethanol extract and n-hexane fraction of Peperomia pellucida. Material and Methods: This research was conducted by make diabetic mice with 50 mg/kg.bw of streptozotocin induction, which was then treated with ethanol extract and n-hexane fraction of Peperomia pellucida with doses 250 mg/kgbw for 7 days. Results: The results showed that the ethanol extract and n-hexane fraction of Peperomia pellucida reduced blood glucose levels in diabetic mice due to streptozotocin induction. The n-hexane fraction of Peperomia pellucida can lower blood glucose levels as much 244.00 ± 18.99 mg/dL better than the ethanol extract, which is 99.50 ± 28.17 mg/dL. Conclusions: Peperomia pellucida herb has the potential to be developed as an antidiabetic agent.
Fakultas MIPA Universitas Tadulako Palu
Title: Antidiabetic Activity of Peperomia pellucida In Streptozotocin-Induced Diabetic Mice
Description:
Background: Diabetes mellitus is a heterogeneous group of diseases in the form of disorders in the body's metabolism clinically.
Peperomia pellucida herbs have phytochemical containing which is antidiabetic potential development.
Objectives: This study was conducted to compare the antidiabetic activity of ethanol extract and n-hexane fraction of Peperomia pellucida.
Material and Methods: This research was conducted by make diabetic mice with 50 mg/kg.
bw of streptozotocin induction, which was then treated with ethanol extract and n-hexane fraction of Peperomia pellucida with doses 250 mg/kgbw for 7 days.
Results: The results showed that the ethanol extract and n-hexane fraction of Peperomia pellucida reduced blood glucose levels in diabetic mice due to streptozotocin induction.
The n-hexane fraction of Peperomia pellucida can lower blood glucose levels as much 244.
00 ± 18.
99 mg/dL better than the ethanol extract, which is 99.
50 ± 28.
17 mg/dL.
Conclusions: Peperomia pellucida herb has the potential to be developed as an antidiabetic agent.
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