Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Olprinone: A Phosphodiesterase III Inhibitor with Positive Inotropic and Vasodilator Effects
View through CrossRef
ABSTRACTOlprinone is a newly developed phosphodiesterase III inhibitor characterized by several properties. First, olprinone has positive inotropic and vasodilator actions and improves myocardial mechanical efficiency. Second, olprinone augments cerebral blood flow by a direct vasodilatory effect on cerebral arteries. The cerebrovascular reactivity to olprinone is marked in patients with impaired cerebral circulation. Third, olprinone selectively improves carotid artery distensibility, which may be attributable to differences in the arterial structural components or the reactivity of smooth muscle cells to olprinone. Fourth, olprinone improves inadequate redistribution of brain perfusion and may prevent cerebral metabolic abnormalities in heart failure.
Title: Olprinone: A Phosphodiesterase III Inhibitor with Positive Inotropic and Vasodilator Effects
Description:
ABSTRACTOlprinone is a newly developed phosphodiesterase III inhibitor characterized by several properties.
First, olprinone has positive inotropic and vasodilator actions and improves myocardial mechanical efficiency.
Second, olprinone augments cerebral blood flow by a direct vasodilatory effect on cerebral arteries.
The cerebrovascular reactivity to olprinone is marked in patients with impaired cerebral circulation.
Third, olprinone selectively improves carotid artery distensibility, which may be attributable to differences in the arterial structural components or the reactivity of smooth muscle cells to olprinone.
Fourth, olprinone improves inadequate redistribution of brain perfusion and may prevent cerebral metabolic abnormalities in heart failure.
Related Results
Alpha 1-adrenoceptor-mediated phosphoinositide breakdown and inotropic response in rat left ventricular papillary muscles.
Alpha 1-adrenoceptor-mediated phosphoinositide breakdown and inotropic response in rat left ventricular papillary muscles.
alpha 1-Adrenoceptor stimulation of rat left ventricular papillary muscles by phenylephrine in the presence of propranolol resulted in rapid breakdown of phosphatidylinositol 4,5-b...
Positive Inotropic Action of Veratridine in Rat Atria: Possible Involvement of Prostanoids
Positive Inotropic Action of Veratridine in Rat Atria: Possible Involvement of Prostanoids
Veratridine caused a positive inotropic action in the electrically driven left atria of rats. Quinacrine (a phospholipase A<sub>2</sub> inhibitor), indomethacin (a cycl...
STUDY THE LEFT VENTRICULAR FUNCTION WITH SPECKLE TRACKING IMAGING IN PATIENTS WITH DILATED CARDIOMYOPATHY AFTER TREATMENT WITH PHOSPHODIESTERASE INHIBITORS-OLPRINONE
STUDY THE LEFT VENTRICULAR FUNCTION WITH SPECKLE TRACKING IMAGING IN PATIENTS WITH DILATED CARDIOMYOPATHY AFTER TREATMENT WITH PHOSPHODIESTERASE INHIBITORS-OLPRINONE
Objectives
The aim of this study is to compare the left ventricular systolic and diastolic function with spackle tracking imaging (STI) in patients with chronic c...
OR-1896 increases force of contraction in the isolated human atrium
OR-1896 increases force of contraction in the isolated human atrium
Abstract
OR-1896 ((R)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl) phenyl)-acetamide) is the main active metabolite of levosimendan. However, nobody has reported ...
Impact of inotropic therapy on mortality in cardiogenic shock following acute myocardial infarction
Impact of inotropic therapy on mortality in cardiogenic shock following acute myocardial infarction
Abstract
Introduction
Cardiogenic shock (CS) complicates 3-13% of acute myocardial infarction (AMI) cases, with a mortality rate...
Comparative effects of L-NNA and alkyl esters of L-NNA on pulmonary vasodilator responses to ACh, BK, and SP
Comparative effects of L-NNA and alkyl esters of L-NNA on pulmonary vasodilator responses to ACh, BK, and SP
The comparative effects of the nitric oxide (NO) synthase inhibitors N omega-nitro-L-arginine (L-NNA), N omega-nitro-L-arginine methyl ester (L-NAME), and N omega-nitro-L-arginine ...
In silico
molecular docking and molecular dynamics of
Prinsepia utilis
phytochemicals as potential inhibitors of phosphodiesterase 4B
In silico
molecular docking and molecular dynamics of
Prinsepia utilis
phytochemicals as potential inhibitors of phosphodiesterase 4B
Phosphodiesterase 4B is an important enzyme belonging to the phosphodiesterase family, playing a role in regulating the levels of cyclic AMP in cells. Phosphodiesterase 4B degrades...
A practice survey on vasopressor and inotropic drug therapy in Scandinavian intensive care units
A practice survey on vasopressor and inotropic drug therapy in Scandinavian intensive care units
Background: This practice survey was performed to analyse the indications for use of vasopressor/inotropic drugs, preferred drugs and doses as well as concomitant monitoring and de...