Genetic association between ICAM-1 gene variants and susceptibility to ischemic cardiomyopathy

AbstractObjective:The current work was aimed at exploring the association between single nucleotide polymorphisms(SNPs) in the ICAM-1 gene, along with the identification of additional haplotypes and their potential role in susceptibility to Ischemic Cardiomyopathy（ICM）.Methods:The control group underwent a Hardy-Weinberg equilibrium test. The associations of genotypes and alleles with susceptibility to ischemic cardiomyopathy were then analyzed using logistic regression. Subsequently odds ratios(ORs) along with 95% confidence intervals (95% CI) were calculated. Interaction analysis was conducted between these SNPs. Furthermore, linkage disequilibrium analysis and haplotype analysis were performed on SNPs that showed interactions with each other.Results:The incidence of ICM was significantly higher among individuals carrying the T allele of rs3093032 (OR = 2.032, 95%CI = 1.275–3.241,P= 0.003)in relative to those with the C allele. Additionally, CT genotype carriers had a higher susceptibility to ICM than CC genotype carriers(OR = 2.490, 95%CI = 1.445–4.29,P= 0.001). Furthermore, three SNPs(rs3093032, rs923366, rs3093030) exhibited a strong interaction with each other, while rs281437 showed no interaction with the other three SNPs. Individuals carrying the Crs3093032-Trs923366-Crs3093030haplotype had an elevated risk of ICM compared with those carrying the Crs3093032-Crs923366-Crs3093030haplotype(OR:2.280, 95%CI:1.568–3.315,P<0.001). Moreover, individuals carrying the Trs3093032-Crs923366-Crs3093030haplotype were more susceptible to ICM than those carrying the Crs3093032-Crs923366-Crs3093030haplotype (OR:2.388,95%CI:1.469–3.880,P<0.001).Conclusion:Regarding rs3093032, individuals carrying the T allele exhibited a higher risk of ICM than those with the C allele. Moreover, CT genotype carriers were more susceptible to ICM than CC genotype carriers. Furthermore, individuals carrying the Crs3093032-Trs923366-Crs3093030and Trs3093032-Crs923366-Crs3093030haplotypes presented an elevated risk of developing ICM compared to carriers of the Crs3093032-Crs923366-Crs3093030haplotype. These findings provide valuable insights into the effects of ICAM-1 gene variants on the intricate pathogenic mechanisms underlying ICM.