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Expression of GRINA Correlates with Prognosis in Human Cancers: A Pan-cancer Analysis
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Abstract
GRINA
is an emerging target for cancer therapy. However, the role of
GRINA
expression and its correlation with cancer patient survival has not been comprehensively studied. Here, we found that mRNA and protein expression of GRINA was upregulated in breast, colon, gastric, and prostate cancers and negatively correlated with patient survival. Also, the upregulation of GRINA expression is associated with hypomethylation of its promoter region. Our GRINA-miRNAs network analysis revealed potential regulatory miRNAs regulating the GRINA expression and its downstream pathways. Next, functional enrichment and pathway analysis of genes commonly co-express with
GRINA
in breast, colon, gastric, and prostate cancers revealed
GRINA
regulatory pathways. Concurrently, our upstream regulator analysis revealed possible kinases, transcription factors, and proteins that may potentially regulate
GRINA
. Overall, this study demonstrates the prognostic significance of
GRINA
expression and identifies potential regulatory mechanisms, which might have significant implications in targeted therapies for human cancers.
Title: Expression of GRINA Correlates with Prognosis in Human Cancers: A Pan-cancer Analysis
Description:
Abstract
GRINA
is an emerging target for cancer therapy.
However, the role of
GRINA
expression and its correlation with cancer patient survival has not been comprehensively studied.
Here, we found that mRNA and protein expression of GRINA was upregulated in breast, colon, gastric, and prostate cancers and negatively correlated with patient survival.
Also, the upregulation of GRINA expression is associated with hypomethylation of its promoter region.
Our GRINA-miRNAs network analysis revealed potential regulatory miRNAs regulating the GRINA expression and its downstream pathways.
Next, functional enrichment and pathway analysis of genes commonly co-express with
GRINA
in breast, colon, gastric, and prostate cancers revealed
GRINA
regulatory pathways.
Concurrently, our upstream regulator analysis revealed possible kinases, transcription factors, and proteins that may potentially regulate
GRINA
.
Overall, this study demonstrates the prognostic significance of
GRINA
expression and identifies potential regulatory mechanisms, which might have significant implications in targeted therapies for human cancers.
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