HISTOMORPHOLOGICAL VARIANTS AND SECONDARY CHANGES IN UTERINE LEIOMYOMA

BACKGROUND: Leiomyoma is one of the most common causes of Abnormal Uterine Bleeding. It occurs chiey in women during active reproductive years. It has a lot of morphological variants and secondary changes which may mimic malignancy clinically, radiologically and histologically. A few degenerative changes and variants like Atypical and Mitotically active Leiomyoma may be misdiagnosed as malignancy. It is imperative to have a good knowledge of Leiomyosarcoma as the treatment protocol varies. AIMS AND OBJECTIVES: To analyse the morphological variants and secondary changes in Leiomyoma and to study the associated changes in the endometrium. MATERIALS AND METHODS: 420 Hysterectomy specimens with Fibroid received at Govt. Kilpauk medical College, Chennai were studied from January 2018 to January 2020. RESULTS: Leiomyoma was seen in the reproductive age group and menorrhagia was the most common clinical presentation. Hyalinisation was the most common secondary change seen in Leiomyoma and cellular leiomyoma was the most common morphological variant. CONCLUSION:A good comprehensive and accurate knowledge of the morphological variants and secondary changes in Leiomyoma mandatory to avoid misdiagnosis and ensuring optimal patient management.