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7. Molecular biology in the clinic
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Environmental agents can cause genetic and epigenetic changes to DNA, the consequences of which lead to deregulation of cellular processes and pathways that cause disease. Genetic variation can either be inherited if acquired through the germline or non-heritable when the DNA changes occur in somatic (body) cells. ‘Molecular biology in the clinic’ discusses two key contemporary areas of clinical research that have benefited from an improved knowledge of their molecular basis: ageing and cancer. It shows that we are now better able to predict disease risk and design drugs that have higher clinical efficacy by targeting specific molecular pathways.
Title: 7. Molecular biology in the clinic
Description:
Environmental agents can cause genetic and epigenetic changes to DNA, the consequences of which lead to deregulation of cellular processes and pathways that cause disease.
Genetic variation can either be inherited if acquired through the germline or non-heritable when the DNA changes occur in somatic (body) cells.
‘Molecular biology in the clinic’ discusses two key contemporary areas of clinical research that have benefited from an improved knowledge of their molecular basis: ageing and cancer.
It shows that we are now better able to predict disease risk and design drugs that have higher clinical efficacy by targeting specific molecular pathways.
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