A STUDY OF ASSOCIATION OF TOTAL CHOLESTEROL, TRIGLYCERIDE TO HDL CHOLESTEROL RATIO WITH HEMORRHAGIC TRANSFORMATION OF ISCHEMIC STROKE

Background: Hemorrhagic transformation (HT) is a well-known complication after ischemic stroke, with its incidence being higher after thrombolysis. Various risk factors like older age, high blood pressure, and poor glycemic control are associated with HT. Recent studies showed associations of low level of Low-density lipoprotein (LDL) cholesterol with HT, however the association of total cholesterol, triglyceride to high density lipoprotein cholesterol (HDL-C) ratio with HT is less frequently studied. In this study, we analyzed the association of total cholesterol level, triglyceride to HDL-C ratio with HT of ischemic stroke. To study the assoc Aims and objectives: iation of total cholesterol level, triglyceride to HDL-C ratio with the HT of ischemic stroke. Data from a total of 100 conse Methodology: cutive patients with ischemic stroke (from 15.05.2023 to 15.08.2023) were collected. Lipid prole including total cholesterol, triglycerides, HDL-C and MRI brain imaging details of HT were collected. All the patients were divided into 4 groups based on total cholesterol level (group 1 – total cholesterol </= 153 mg/dl, group 2 – 153 to 177 mg/dl, group 3 – 178 to 202 mg/dl, group 4 >202 mg/dl). HT and its association with lipid prole was assessed. Of 100 patients, Results and conclusions: 34 (34%) had HT. 16 out of 34 (47.1%) had HT in group 1. 8 out of 19 (42.1%) had HT in group 2. 4 out of 15 (26.7%) had HT in group 3. 6 out of 32 (18.8%) had HT in group 4. The triglyceride to HDL ratio was in the range of 2.1 to 6.1 among 31.5% of patients with HT. From our study we concluded that HT occurred more commonly in groups 1 and 2, however this association was not statistically signicant. Triglyceride to HDL-C ratio had no signicant association with HT.