The Pharmacological Study on Therapeutic Efficacy of the Herbal Preparation of Hypericum

Dyspepsia is a condition associated with digestive disorders, including diarrhea, weakness, dehydration, and intoxication. The investigation and application of therapeutic and prophylactic agents for managing gastrointestinal diseases in young cattle, including dyspepsia in newborn calves, is concerning. The present study aimed to investigate the biochemical mechanisms of action of Hypericum in the treatment of dyspepsia in newborn calves. Two groups of black and white breed bulls (five animals per group), aged 8-10 days, were assigned to assess the effects of Hypericum on biochemical parameters, including total protein, albumin, glucose, bilirubin, urea, creatinine, aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase. Calves in the first group (n = 5), exhibiting pronounced signs of dyspepsia, were administered the treatment. This treatment consisted of 250 mL of Hypericum, combined with 500-700 mL of warm water, instead of milk, during the following two feedings. Then, milk was added to each serving of this mixture until the total volume reached 1.25-1.50 liters, and it was given to calves until clinical signs of recovery appeared. Calves of the second group (n = 5) were clinically healthy and received boiled water instead of the Hypericum. The current findings demonstrated that the biochemical parameters of the experimental calves improved following the administration of Hypericum, reaching levels comparable to those of clinically healthy calves. After prophylactic administration of Hypericum at a dose of 6.5 mL/kg during the first six feedings, the general condition of the experimental calves was satisfactory. In the experimental group of calves administered Hypericum at a dosage of 6.5 mL/kg mixed with milk over a period of two days, only one out of fifteen calves exhibited signs of dyspepsia, including liquid feces and lethargic behavior within the initial four days, representing a prevalence of 6.7%. Hypericum could prevent the occurrence of dyspepsia by 93%. The utilization of Hypericum had a therapeutic influence and positively impacted the clinical condition, behavior, and appetite of the calves.