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Osteopontin Modulates Prostate Carcinoma Invasive Capacity through RGD-Dependent Upregulation of Plasminogen Activators
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Abstract
Osteopontin, a noncollageneous bone matrix protein,
is produced in several human tumors but its role
in cancer progression has been only partially elucidated.
In this study we investigated the potential role
of osteopontin in the malignancy of prostate cancer
cells. Chemotaxis and chemoinvasion analyses revealed
a dosedependent increase in PC3 cell movement
induced by osteopontin and a strict dependence
of cell invasion on αvβ3 integrin function. The
pattern of protease expression was modified by osteopontin
and was characterized by an upregulation
of plasminogen activators. Our findings suggest that
osteopontin may confer selective malignant potential
to prostate cancer cells through the enhancement of
their invasive and proteolytic capability.
Walter de Gruyter GmbH
Title: Osteopontin Modulates Prostate Carcinoma Invasive Capacity through RGD-Dependent Upregulation of Plasminogen Activators
Description:
Abstract
Osteopontin, a noncollageneous bone matrix protein,
is produced in several human tumors but its role
in cancer progression has been only partially elucidated.
In this study we investigated the potential role
of osteopontin in the malignancy of prostate cancer
cells.
Chemotaxis and chemoinvasion analyses revealed
a dosedependent increase in PC3 cell movement
induced by osteopontin and a strict dependence
of cell invasion on αvβ3 integrin function.
The
pattern of protease expression was modified by osteopontin
and was characterized by an upregulation
of plasminogen activators.
Our findings suggest that
osteopontin may confer selective malignant potential
to prostate cancer cells through the enhancement of
their invasive and proteolytic capability.
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