Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
The Solubility-Permeability Interplay for Solubility-Enabling Oral Formulations
View through CrossRef
The Biopharmaceutical classification system (BCS) classifies the drugs based on their intrinsic
solubility and intestinal permeability. The drugs with good solubility and intestinal permeability
have good bioavailability. The drugs with poor solubility and poor permeability have solubility dependent
and permeability dependent bioavailability, respectively. In the current pharmaceutical field,
most of the drugs have poor solubility. To solve the problem of poor solubility, various solubility enhancement
approaches have been successfully used. The effects of these solubility enhancing approaches
on the intestinal permeability of the drugs are a matter of concern, and must not be overlooked.
The current review article focuses on the effect of various solubility enhancing approaches viz.
cyclodextrin, surfactant, cosolvent, hydrotropes, and amorphous solid dispersion, on the intestinal
permeability of drugs. This article will help in the designing of the optimized formulations having balanced
solubility enhancement without affecting the permeability of drugs.
Bentham Science Publishers Ltd.
Title: The Solubility-Permeability Interplay for Solubility-Enabling Oral Formulations
Description:
The Biopharmaceutical classification system (BCS) classifies the drugs based on their intrinsic
solubility and intestinal permeability.
The drugs with good solubility and intestinal permeability
have good bioavailability.
The drugs with poor solubility and poor permeability have solubility dependent
and permeability dependent bioavailability, respectively.
In the current pharmaceutical field,
most of the drugs have poor solubility.
To solve the problem of poor solubility, various solubility enhancement
approaches have been successfully used.
The effects of these solubility enhancing approaches
on the intestinal permeability of the drugs are a matter of concern, and must not be overlooked.
The current review article focuses on the effect of various solubility enhancing approaches viz.
cyclodextrin, surfactant, cosolvent, hydrotropes, and amorphous solid dispersion, on the intestinal
permeability of drugs.
This article will help in the designing of the optimized formulations having balanced
solubility enhancement without affecting the permeability of drugs.
Related Results
Permeability Prediction for Carbonates: Still a Challenge?
Permeability Prediction for Carbonates: Still a Challenge?
Abstract
Permeability estimation for a well and mapping it for a field are extremely critical and difficult tasks in hydrocarbon exploration and production. Diffe...
Comparative Study on Stress-dependent Permeability of Ultra-low Permeability Sandstone Rock Using Different Types of Fluid Media
Comparative Study on Stress-dependent Permeability of Ultra-low Permeability Sandstone Rock Using Different Types of Fluid Media
Abstract
During the production lifecycle of a reservoir, rock permeability may change due to the increase of the effective stress which could significantly affect...
Rock Permeability Measurements Using Drilling Cutting
Rock Permeability Measurements Using Drilling Cutting
Abstract
The current available equipment used in the laboratory to measure permeability of the core samples is very limited. This is because permeability is measu...
Developing a Proficient Relative Permeability Resource From Historical Data
Developing a Proficient Relative Permeability Resource From Historical Data
Abstract
Having reliable and readily accessible relative permeability information is a problem for many reservoir engineers. In the absence of laboratory measured...
Selection of Injectable Drug Product Composition using Machine Learning Models (Preprint)
Selection of Injectable Drug Product Composition using Machine Learning Models (Preprint)
BACKGROUND
As of July 2020, a Web of Science search of “machine learning (ML)” nested within the search of “pharmacokinetics or pharmacodynamics” yielded over 100...
Dynamic-To-Static Permeability Ratio Provides Valuable Insights of Reservoir Architecture and Heterogeneity in Complex Hydraulically Fractured Reservoirs
Dynamic-To-Static Permeability Ratio Provides Valuable Insights of Reservoir Architecture and Heterogeneity in Complex Hydraulically Fractured Reservoirs
Matrix permeability is a key parameter to predict reservoir deliverability and ultimate recovery in tight gas reservoirs. Since it is a multiscale property, its values can signific...
Exponential Growth in San Juan Basin Fruitland Coalbed Permeability With Reservoir Drawdown—Model Match and New Insights
Exponential Growth in San Juan Basin Fruitland Coalbed Permeability With Reservoir Drawdown—Model Match and New Insights
Abstract
The exponential growth behaviour of coalbed permeability with reservoir pressure depletion has previously been observed at the Fairway wells in the San Juan...
The Effect of Fracturing Fluid Leak-off On the Productivity of High Permeability Oil Reservoirs
The Effect of Fracturing Fluid Leak-off On the Productivity of High Permeability Oil Reservoirs
Abstract
During fracturing of high permeability reservoirs hydraulically there is always a concern that fracturing fluid leak-off may cause a reduction in permeab...