Oral Fordyce’s Granules and Serum Lipid Profile; any Relationship?

Background: Sebaceous glands are normal structures of the skin, but may be ectopically found in themouth, as oral Fordyce granules. They are located just beneath the overlying epithelium and are visiblethrough the epithelium producing local elevations. It has been suggested that there is a relation betweenelevated lipid profile and the presence of these granules.Method: A total of 130 individuals were included in this cross-sectional study, who were subjected to theoral examination for the presence & scoring of oral Fordyce granules, then blood samples were taken. Casesheet involved, demographic information and medical history. Using specialized kits, lipids profile analysiswas done on a fully automated spectrophotometric analyzer.Results: Fordyce granules were recorded in 25% of cases, with males formed the majority of them. In bothgender, lip was the most commonly affected sites.Fordyce granules were observed in one-third of patients with systemic diseases.The majority of cases with Fordyce granules, recoded normal triglyceride, HDL, LDL and VLDL levels, butone-fourth of patients with hyper cholesterol were seen with Fordyce granules. Chi-Square test showed noassociation between lipid profile & these granules.A negative correlation was found between Fordyce granules number and cholesterol, HDL and LDL levels,although statistically non- significant.Conclusion: Oral Fordyce granules were most frequently observed in the lips, with male gender and olderage predilections. The current study did not support the association between oral Fordyce granules andserum lipid profile changes.